Ana will face Japan's Ayumi Morita in the first round of the Bank of the West Classic, which begins in Stanford on Monday.
It will be the second meeting between the pair, following Ana's 6-1, 6-2 victory over the 21-year-old in a Fed Cup tie two years ago.
The winner of the contest will meet a qualifier in round two, with third seed Marion Bartoli a possible quarter-final opponent. Top seed Victoria Azarenka is a possible adversary in the semi-finals.
The leading competitors in the bottom half of the draw, whom Ana cannot face until the final, are No.2 seed Maria Sharapova, No.4 Samantha Stosur and 13-time Grand Slam champion Serena Williams.
Ana is seeded seventh in the 28-player draw. She is making her second appearance in Stanford, having reached the second round last year.
